Which is a side effect of magnesium sulfate administration?

Magnesium sulfate is commonly administered in the obstetric setting, particularly for the management of preeclampsia and eclampsia, as well as to prevent seizures. One significant side effect of magnesium sulfate administration is the potential for neuromuscular blockade, which can result in weak or absent deep tendon reflexes (DTRs). This occurs because magnesium competes with calcium at the neuromuscular junction, which is essential for muscle contraction and reflex activity.

When magnesium levels rise due to administration, the physiological effect is a decrease in neuromuscular excitability, leading to diminished reflexes. Monitoring deep tendon reflexes is crucial in patients receiving this therapy, as the presence of absent or weak reflexes can be an indicator of magnesium toxicity, necessitating adjustments in dosing or even cessation of the infusion.

Understanding this side effect is vital for healthcare providers to ensure patient safety and to effectively monitor and manage therapy while minimizing the risk of complications associated with magnesium sulfate.